Antibiotic resistance of extended spectrum β-lactamases (ESBLs)-producing escherichia coli and klebsiella pneumoniae in clinical dubious isolates

Objective To study the characteristic about antibiotic resistance of extended-spectrum β-lactamases(ESBLs)-producing Escherichia coli(E. coli) and Klebsiella pneumoniae (K. pneumoniae) for guiding the clinical drug using.Methods The ESBLs produving dubious E. coli and K. pneumoniae were isolated form all sorts of specimens from July 2008 to Dec. 2008 by the method recommended by the National Committee for Clinical Laboratory Standard (NCCLS),and then detect the ESBLs through the confirmatory test.Results Among 248 strains ,there were 117 strains of E. coli and K. pneumoniae belonging to suspected ESBLs-producing strains,and 82 were confirmed ESBLs producing strains,with the positive ratio being 33.1%. All of the ESBLs-producing strains were resistant to penicillins,with the rate of resist to some of the 3rd ceph-alosporin being 100.0%,the rate of resist to sulfonamides and quinolones being 60.0%～90.0%,and imipenem being 0.0%. Conclusion The resistant rate of the ESBLs-producing E. coli and K. pneumoniae had better activity than that of non ESBLs to antimicrobial; the sensitive rate of the ESBLs-producing strains to aminoglycoside was relatively high. So imipenem is the best drug for the ESBLs-producing strain.