Comparative study of antibiotic resistance in clinical isolates of Klebsiella pneumoniae and Escherichia coli producing extended-spectrum beta lactamases

Objective To determine the prevalence of strains producing ESBLs among Klebsiella pneumoniae and Escherichia coli, and investigate the antibiotic resistance of these strains. Methods 62 strains of ESBLs producing E. coli and K. pneumoniae were determined by a double disk synergy test and antibiotic susceptibility test by Kirby Bauer test. Results The prevalence of ESBLs in isolates of 154 E. coli and K. pneumoniae was 40.3%, the resistance rate of ESBLs producing strains to ceftazidime, cefotaxime, ceftriaxone was 77.0%～94.0%, a higher than that of non ESBLs producing strains. ESBLs producing strains had higher resistance rate to aminoglycosides, quinolones, sulfonamides (96 3%, 85 2%, 92 6%, respectively). All tested strains However, were susceptible to imipenem. Conclusions To deal with the ESBLs producing strains, such antibiotics as imipenem, cefoxitin, β lactama/ β lactamase inhibitor combinations and others which are sensentive to such strains can be used.