ScholarLens Back to search
2005•The Chinese Journal of Modern Applied PharmacyRequires access

Protective effects of glutamine on rats with acute hepatic failure

Wen-bao Huang

Open publisher page 0 citations

Abstract

OBJECTIVE The present experiments were designed to study the protective effects of glutamine on rats with acute hepatic failure.METHODS Establishing the acute hepatic failure models by intraperitoneal injection of galatosamine.Biochemical indexes and histopathological examination were determined. RESULTS At 24 hours,48 hours after intraperitoneal injection of galatosamine,biochemical indexes(ALT,AST,TBIL) level in the glu-treated group were significantly lower than those of the model group(P(0.05)).Histopathological examinations indicated that the glu-treated group had much slighter lesion compared with the model group(P0.05).CONCLUSION The present results showed that glutamine can effectively lighten galatosamine-induced liver necrosis.

About this research paper

What this paper is about

OBJECTIVE The present experiments were designed to study the protective effects of glutamine on rats with acute hepatic failure.METHODS Establishing the acute hepatic failure models by intraperitoneal injection of galatosamine.Biochemical indexes and histopathological examination were determined. RESULTS At 24 hours,48 hours after intraperitoneal injection of galatosamine,biochemical indexes(ALT,AST,TBIL) level in the glu-treated group were significantly lower than those of the model group(P(0.05)).Histopathological examinations indicated that the glu-treated group had much slighter lesion compared with the model group(P0.05).CONCLUSION The present results showed that glutamine can effectively lighten galatosamine-induced liver necrosis.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

OBJECTIVE The present experiments were designed to study the protective effects of glutamine on rats with acute hepatic failure.METHODS Establishing the acute hepatic failure models by intraperitoneal injection of galatosamine.Biochemical indexes and histopathological examination were determined. RESULTS At 24 hours,48 hours after intraperitoneal injection of galatosamine,biochemical indexes(ALT,AST,TBIL) level in the glu-treated group were significantly lower than those of the model group(P(0.05)).Histopathological examinations indicated that the glu-treated group had much slighter lesion compared with the model group(P0.05).CONCLUSION The present results showed that glutamine can effectively lighten galatosamine-induced liver necrosis.

Key concepts: Glutamine, Liver failure, Intraperitoneal injection, Acute hepatic failure, Medicine, Histopathological examination, Normal group, Lesion

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Protective effects of glutamine on rats with acute hepatic failure — Research Paper | ScholarLens