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THE CHANGE OF PLASMA SOLUBLE INTERCELLULAR ADHESION MOLECULE-1 LEVEL IN PATIENTS WITH MALIGNANT TUMOR AND ITS CLINICAL SIGNIFICANCE

Chengyu Liu

Abstract

Objective To explore the changes of plasma soluble intercellular adhesion molecule 1(sICAM 1) level in patients with malignant tumor and its clinical significance. Methods The change of plasma sICAM 1 level was measured by ELISA in 66 patients with malignant tumor and 36 healthy subjects. Results The plasma sICAM 1 level was significantly higher in patients with malignant tumor than that in controls (t=20.560,P0.001),The sICAM 1 level in patients with metastasis and death was higher than that in patients without metastasis and survivors (t=12.725,25.919,P0.001).The sICAM 1 level in patients before operation was higher than that in patients after operation(t=11.179,P0.001). Conclusion The changes of sICAM 1 were closely related to the severity of illness,with or without metastasis,and effects of treatment in patients with malignant tumor

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Key concepts: Medicine, Metastasis, Clinical significance, Internal medicine, Intracellular, Intercellular Adhesion Molecule-1, Adhesion, Cancer