Drug resistance of ESBLs-producing Escherichia coli and Klebsiella pneumoniae from specimens of lower respiratory tract infection

Objective To investigate the drug resistance of ESBLs-producing Escherichia coli and Klebsiella pneumoniae from specimens of lower respiratory tract infection from 2010 to 2011,and to provide clinical guidance for the rational use of antimicrobial drugs.Methods MicoScaWalkway40SI and disk diffusion method were used for strain identification and susceptibility testing.The bacterial distribution and drug resistance were analyzed.Results The detection rate of ESBLs-producing Escherichia coli and Klebsiella pneumoniae in lower respiratory tract in our hospital was 89.2% and 42.6% in 2010,and 84.6% and 46.2% in 2011.The ESBLs-producing strains were resistant to most antibiotics,with low resistance to imipenem,piperacillin/tazobactam,amikacin,cefoxitin.Conclusion The incidence of Escherichia coli and Klebsiella pneumoniae producing ESBLs shows no significant change in the past two years.The timely monitoring of the incidence of ESBLs-producing strains and the drug resistance trends is of great significance in guiding the clinical rational use of antibiotics and the control of hospital infection.