Analysis of Drug Resistance of β-ESBLs-producing Escherichia Coli and Klebsiella Pneumonia

Objective:To analyze the drug resistance of β-ESBLs producing escherichia coli and klebsiella pneumonia pathogens,in order to provide important reference for the clinical rational use of antimicrobial agents.Method:6931 clinical specimens were collected in our hospital from January to December 2014.Drug sensitivity test was conducted by using K-B method and WHONET-5 system was used to analyze the distribution of drug resistant pathogens.Result:2724 positive samples were isolated from 6931 specimens.In the 2724 positive samples,309 escherichia coli strains and 147 strains of klebsiella pneumoniae were isolated.Among them β-ESBLs-producing escherichia coli bacteria had 234 strains,the isolation rate was 75.73%,β-ESBLs-producing klebsiella pneumoniae had 71 strains,the isolation rate was 48.30%.20 strains of the 234 β-ESBLs-producing escherichia coli were resistant to carbapenem antibiotics,accounting for 8.75%.10 strains of 71 β-ESBLs-producing positive klebsiella pneumoniae were resistant to carbapenem antibiotics,accounting for 14.08%.The drug resistant rates of the two pathogens to Imipenem,Meropenem,Piperacillin,Tazobactam,Cefoperazone and Sulbactam were lower.Conclusion:In our hospital,the separation rates of β-ESBLs-producing escherichia coli and klebsiella pathogenic were higher in 2014.They has high drug resistance rates and multiple drug resistance phenomeno.We must strengthen the monitoring of drug resistance of β-ESBLs-producing bacteria,provide the results of drug sensitivity test for clinical timely and accurately,promote the rational use of antimicrobial drugs,in order to prevent the outbreak or epidemic of β-ESBLs-producing bacteria in nosocomial.