Hospital Acquired Infection of Low Respiratory Tract by Klebsiella pneumoniae and Escherichia coli and Their Antibiotic Resistance

OBJECTIVE To investigate the prevalence and resistance of ESBLs producing strains in Klebsiella pneumoniae and Escherichia coli isolated from patients with hospital acquired infection of low respiratory tract by them and to explore the risk factors of the occurrence of ESBLs strains.METHODS A total of 114 cases with hospital acquired infection of low respiratory tract by K. pneumoniae and E. coli were collected. Bacterial susceptibility testing was done by Microscan WalkAway 40, results were assessed according to NCCLS2000.RESULTS The incidence of ESBLs producing strains was 40.0% in E. coli and 21.6% in K. pneumoniae with the overall incidence of 28.1%. The incidence of ESBLs producing strains was 58.6% in E. coli and K. pneumoniae in RICU, it was significantly higher than that in respiratory ward (17.6%,P 0.001). ESBLs producing strains were sensitive to imipenem (100%), the sensibility to piperacillin/tazobactam and cefoperazone/sulbactam was 62.5% and 59.3% , respectively.CONCLUSIONS Piperacillin/tazobactam and cefoperazone/sulbactam are also relatively susceptible drugs in clinical therapy. Reducing the use of hormones and antacid and invasive operation, improving nutritional status may decrease the infection of ESBLs strain.