Therapeutic Effect of Iron Sucrose and Erythropoietin on Renal Anemia

Objective To determine the efficacy and safety of intravenous iron sucrose with oral ferrous succinate in renal anemia patients. Methods 50 hemodialysis patients were randomized into two groups: Intravenous iron group(IV group) with 100 mg iron sucrose,twice a week and Oral iron group(Oral group) with 300 mg ferrous succinate every day.The changes in hemoglobin(Hb),hematocrit(Hct),serum ferritin(SF),and transferrin saturation(TSAT) were assessed on week 4,8,and 12 after treatment.The maintenance dosages of erythropoietin(EPO) after reaching treatment target and the adverse events were also observed. Result There is higher increase of Hb,Hct,SF,and TSAT in IV group compared with Oral group.The adverse events and maintenance dosages of EPO is lower in IV group. Conclusion Oral iron which has more adverse events has poor efficacy in curing anemia that cannot correct anemia ideally.Meanwhile iron sucrose has positive effects on renal anemia with low adverse events,and it can be used as a long term iron supplementation in hemodialysis patients.