Efficacy and safety of intravenous iron sucrose combined with erythropoietin in the treatment of anemia in maintenance hemodialysis patients

Objective To investigate and compare the efficacy and safety of intravenous iron sucrose with oral polysaccharide iron complex in erythropoietin treated in maintenance hemodialysis patients.Methods A randomized and controlled clinical study was used.Forty-two maintenance hemodialysis patients were devided into two groups,iv group and oral group,and were treated with the intravenous iron sucrose and oral polysaccharide iron complex separately.Results Hemoglobin(Hb),hemotocrit(Hct),serum ferritin(SF)and transferrin saturation(TSAT)were significantly increased in both groups.However,the increment of these laboratory parameters was significantly higher in iv group than in oral group(P0.05).There were less adverse effects in iv group than in oral group(P0.05).Conclusion Intravenous iron sucrose is effective and safety in treating anemic maintenance hemodialysis patients.It may induce Hb level to rise faster with less adverse effect.