Clinical research of plasma exchange treatment on severe hepatitis

Objective To study the clinical efficacy,timing and safety of plasma exchange treatment on severe hepatitis.Methods From September 2006 to December 2009,165 cases with severe hepatitis were selected,who were hospitalized in the department of infectious diseases,Jianyang city people's hospital.The patients were divided into treatment group (medical therapy plus plasma exchange,n=89 cases),as well as the control group (medical therapy alone,n=76 cases).After 4 weeks,The treatment efficacy were compared.Results After plasma exchange treatment,the symptoms,spirit,appetite,physical strength of patients were significantly improved.Compared with pretreatment,The serum TBIL,ALT,AST,PTA levels were significantly improved at the end of plasma exchange treatment (P 0.01).After treatment for 4 weeks,the total effective rate of treatment group was significantly higher than control group(P 0.01).The effective rate of the early stage,medium stage of severe hepatitis (85.71%,71.87%) in treatment group,were higher than the control group (63.16%,53.85%),respectively.The two groups were significantly different (P 0.01).Severe adverse reactions were not found in plasma exchange treatment.Conclusions The plasma exchange treatment of severe hepatitis has a certain effect.The clinical efficacy of plasma exchange using in early and middle stage of severe hepatitis is better than using in the late stage.