The evaluation of the PE to treat the chronic severe hepatitis.

Objective To evaluate the efficacy and opportunity and the safety of artificial liver-plasma exchange in patients with chronic severe hepatitis.Methods To choose 83 cases of the chronic severe hepafitis,comparing the main changes of the laboratory target before and after the treatment.80 patients who were not treated with plasma-exchange(PE) were used as contracting group.The aim is to compare the effectiveness,total effectiveness and recent living rate on the different period.Results There were an improvement of the symptoms,spirit,appetite and body-building.And there were significant differences of serum levels of ALT、AST、TBil、DBil、PT、PTA between before and after ALSS therapy in the treatment group.The improvement rates of early and middle period patients in ALSS treatment group were 87.10% and 69.70%.and the total effectiveness rate was 63.86%.Comparing with the former,the results of control group were 51.85%,38.71% and 37.50%,respectively.There were significant differences between the two groups,respectively(P0.05).At the recent living rate(four weeks),the treatment group is absolutely higher than the contracting group.The results were 71.08% and 42.05% respectively.There were significant differences between the two groups,respectively(P0.01).Conclusions ALSS treatment can improve the biochemistry of patients suffering from severe hepatitis.It is more suitable to use PE in early and middle stage of chronic severe hepatitis.Artificial liver supporting system is the comparatively mature liver replace therapy until now.It's also one of the safe and effective measures to treat the severe hepatitis.