2009•Journal of clinical and experimental medicineRequires access
Eradication of Helicobacter pylori with ten days sequential therapy and standard triple therapies
Jia Liu
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Abstract
Objective To evaluate the eradication of ten days sequential therapy consisted of omeperazole,clarithromycin,amoxicillin and tinidazole on Helicobacter pylori(Hp)infection.Methods 210 patients with Hp positive were randomly divided into two groups.110 patients were treated with omeperazole,amoxicillin at first five days,omeperazole,clarithromycin and tinidazole at the second five days.The control group(110 patients)were treated with omeperazole,clarithromycin and amoxicillin for ten days.Results The eradication rate of ten days sequential therapy was 92.4% and that of control group was 78.1%.The differences between two groups were significant(P0.05).Conclusion Ten days sequential therapy is more effective,well tolerated and with higher rate of eradication.