Effects of Sequential Therapy for Helicobacter Pylori Eradication in Children

Objective To compare the effectiveness of standard triple therapy and a new sequential therapy for Helicobacter pylori eradication in children.Methods A total of 120 Helicobacter pylori positive children were enrolled in the study and randomly allocated into two groups.The first group(n=60) received the sequential therapy(omeprazole+amoxicillin and clavulanate potassium for the first 5 days and followed by omeprazole+tinidazole+clarithromycin for the remaining 5 days);the second group(n=60) received a standard 10-day triple therapy(omeprazole+amoxicillin and clavulanate potassium+clarithromycin).Eradication rates were determined 4 weeks after the treatment by urea breath test.Eradication rates were calculated.Results The eradication rate was 91.7%(55/60) in children with sequential therapy,but not achieve the statistic significant comparing with 10-day standard triple therapy(86.7%,52/60),P0.05.The two treatment protocols were generally well tolerated.Conclusion Sequential therapy is effective for eradicating Helicobacter pylori but do not achieve statistically significant compared with 10-day standard triple therapy.