The study on Eradication of Helicobacter pylori Using Sequential Therapy

Objective To evaluate the eradication of ten days sequential therapy consisted of Pantoprazole,Clarithromycin,Amoxicillin and Levofloxacin on Helicobacter pylori(Hp) infection.Methods Totally 115 Helicobacter pylori-infected patients with peptic ulcer or chronic gastritis diagnosed by gastroscopy were enrolled.The patients were randomized divided as trial group(58 patients) who received Pantoprazole,Levofloxacin for the first five days,and followed by Pantoprazole,Amoxicillin and Clarithromycin for the last five days;the control group(57 patients) were treated with Pantoprazole,Amoxicillin and Clarithromycin for seven days,then contrast the eradication rates.Results The eradication rates of Hp in the trial group was 93.0%,and the numbers in the control group was 81.9%,which were significantly lower than those in the sequential therapy group(P0.05).Conclusions The ten days sequential therapy consisted of Pantoprazole and Levofloxacin,Amoxicillin,Clarithromycin has a better H.pylori eradication effect and tolerability than standard triple therapy.