Prophylaxic effects of tropisetron on postoperative nausea and vomiting

Objective To observe the prophylactic effect of tropisetron on postoperative nausea and vomiting(PONV). Methods Ninety patients scheduled for celioscope cholecystectomy under intravenous-inhalation general anesthesia were randomly divided into three groups,preoperative group(GroupⅠ, n=30):tropisetron was given prior to the inductionof anesthesia, postoperative group(GroupⅡ, n=30) :tropisetron was given at the end of the surgery and control group(GroupⅢ, n=30):no tropisetron was given. The incidence of nausea and vomiting was observed and recorded during 24h after surgery. Results The frequency of nausea and vomiting was 27%and 20%in GroupⅠ, 30%and 23%in GroupⅡand 50%and 37%in Group Ⅲ. There was no significantly difference between GroupⅠand GroupⅡ(P 0.05) and were significantly differences between Group Ⅲand GroupⅠor GroupⅡ(P 0.05 and 0.05). Conclusion Under the same dose, tropisetron given either before surgery or after surgery can effectively reduce the incidence of postoperative nausea and vomiting, of which the former is better than the latter.