Effects of administration of tropisetron at different times to prevent intraoperative and postoperative nausea and vomiting of anorectum surgery

AIM To observe the effects of administration of tropisetron at different time to prevent intraoperative and postoperative nausea and vomiting(IONV and PONV)of anorectum surgery under the combined spinal and epidural anesthesia(CSEA).METHODS Eighty patients scheduled for anorectum surgery with CSEA were randomly divided into four groups,20 in each.The patients in the group C were not administered tropisetron.The patients in the groupⅠwere administered tropisetron 5 mg by intravenous after anesthesia.The patients in the groupⅡwere administered tropisetron 2 mg by intravenous after anesthesia and 3 mg after the operation.In groupⅢ,the patients were administered tropisetron 5 mg by intravenous after the operation.The occurrences of nausea and vomiting during operation and 24 hours after operation were observed.RESULTS Compared with the group C,the incidences of IONV were significantly lower in the groupⅠandⅡ,and the incidences of PONV were significantly lower in the groupⅠ,Ⅱand Ⅲ(P 0.05).The incidences of PONV in the group Ⅱ and Ⅲ were significantly lower than that in the groupⅠ(P 0.05).No over sedation and extrapyramidal symptoms occurred in four groups.CONCLUSION Preoperative and postoperative adminis-tration of tropisetron can effectively reduce the occurrence of nausea and vomiting.