Pathological analysis of Cervical intraepithelial neoplasia of the loop electrosurgical excision procedure and colposcopy biopsy

Objective To explore the value of loop electrosurgical excision procedure(LEEP)and cervical biopsy by colposcopy in the diagnosis of cervical intraepithelial neoplasia(CIN).Methods Retrospective analyze out-patient information of 123 cases of CIN diagnosised by cervical biopsy by colposcopy,which were compared with pathological results by LEEP.Results There were 16 Chronic cervicitis,21 CIN I,40 CIN II,40 CIN III,4 early invasive carcinoma,2 Invasive carcinoma in 123 patients diagnosis by LEEP.Coincidence rate of pathological results CIN I,CIN II,CIN III between cervical biopsy by colposcopy and LEEP was 43.9%,73.8%,85.0%,respectively,and the total Coincidence rate was 67.5%.19 cases(15.5%)were in higher grade in the pathological results of colposcopic multiple biopsy than in those of LEEP,and other 21 cases(17.1%)were in lower grader.The missed diagnosis rate of cervical cancer was 4.9%.Accuracy of cervical biopsy by colposcopy on CIN II and CIN III was higher than that of CIN I.There was significant difference between them(P0.01).The missed diagnosis rate of cervical cancer by cervical biopsy under colposcopy in CIN III was higher than that in CIN I and CIN II(P0.05).Conclusion Cervical biopsy by colposcopy is a simple,effective method in the diagnosis of CIN,but there are some limitations.LEEP can make up the defects of cervical biopsy by colposcopy and improve the accuracy of diagnosis.