Clinical Effectiveness of Ranitidine Bismuth Citrate Based Triple Therapy for Eradicating Helicobacter Pylori

Objective To study the saety and effectiveness of ranitidine bismuth citrate(RBC) based triple therapy in eradicating Helico-bacter pylori(Hp).Methods 147 patients with Hp-positive were randomly divided into 3 groups:RBC therapy group,Omeprazole therapy groupand Ranitidin therapy group.Hp eradication was assessed by14C-urea breath test and real-time quantitative PCR4 weeks after completion of1 weektriple therapy regimen.Results The intent-to-treat(ITT) and per-protocol(PP) eradication rates were statisticaly equivalent between RBC group(83.7% ITT,87.2%PP) and omeprazole group(87.5% ITT,93.3% PP).Incidence of adverse events and improvement of symptoms did not dif-fer between the above two groups.However,the eradication rates in RBC group were higher than that in Ranitidine group significantly.Incidence ofadverse events in RBC group was lower than that in Ranitidine group.Conclusion The clinical effect of RBC based one week triple therapy is sim-ilar to Omeprazole triple therapy and better than Ranitidine triple therapy.Therefore,it is recommended as the first-line regiment for eradicaing Hp.