Comparison of ranitidine bismuth citrate and omeprazole-based regimens in the treatment of Helicobacter pylori infection

Objective To study the efficacies of ranitidine bismuth citrate(RBC)-based triple therapy with omeprazole-based triple therapies in the treatment of Helicobacter pylori(Hp) for one week.To evaluate the safety of the all therapies.Methods 65 patients with Hp-positive gastritis diagnosed by endoscopy were randomized to received one of the following regimens for 7 days: group A,RBC 350 mg,amoxicillin 1 g,metronidazole 400 mg and group B,omeprazole 20 mg amoxicillin 1g,metronidazole 400 mg(all given twice daily for one week).Four weeks after finishing medication,13Curea breath test were performed.Results The Hp eradication rates of the group A and group B were 84.8% and 84.4% respectively(P0.05).The pain-relieving rates of two groups were 86.4% and 82.6%(P0.05).The side effects were mild in both groups.Conclusion The RBC-based regimen is effective and well tolerated for the eradication of Hp.The efficacies of Hp eradicating were similar among the two groups.