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2011•Journal of Medical Science Yanbian UniversityRequires access

Protective effects of the Gankang paste on acute liver injury induced by carbon tetrachloride in mice

Yanhua Han

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Abstract

OBJECTIVE To study the protective effects of Gankang paste on acute liver injury induced by carbon tetrachloride(CCl4) in mice.METHODS The acute hepatic injury models in mice were established by the subcutaneous injection with the CCl4,and 2.00,1.00,0.50 g/kg of the Gankang paste extract were intragastrically administrated,and the activity of ALT in serum,content of MDA and activities of SOD and GSH-Px in liver were detected by colorimetric method.RESULTS As compared with the model control group,the activity of ALT in serum was significantly increased(P0.01),and the content of MDA in liver were significantly decreased(P0.01) in large,middle and small dosages of the Gankang paste groups,and the activities of SOD and GSH-Px in liver were significantly increased(P0.01,P0.05).CONCLUSION The Gankang paste has protective effects for acute liver injury induced by CCl4 in mice.

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OBJECTIVE To study the protective effects of Gankang paste on acute liver injury induced by carbon tetrachloride(CCl4) in mice.METHODS The acute hepatic injury models in mice were established by the subcutaneous injection with the CCl4,and 2.00,1.00,0.50 g/kg of the Gankang paste extract were intragastrically administrated,and the activity of ALT in serum,content of MDA and activities of SOD and GSH-Px in liver were detected by colorimetric method.RESULTS As compared with the model control group,the activity of ALT in serum was significantly increased(P0.01),and the content of MDA in liver were significantly decreased(P0.01) in large,middle and small dosages of the Gankang paste groups,and the activities of SOD and GSH-Px in liver were significantly increased(P0.01,P0.05).CONCLUSION The Gankang paste has protective effects for acute liver injury induced by CCl4 in mice.

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Available abstract

OBJECTIVE To study the protective effects of Gankang paste on acute liver injury induced by carbon tetrachloride(CCl4) in mice.METHODS The acute hepatic injury models in mice were established by the subcutaneous injection with the CCl4,and 2.00,1.00,0.50 g/kg of the Gankang paste extract were intragastrically administrated,and the activity of ALT in serum,content of MDA and activities of SOD and GSH-Px in liver were detected by colorimetric method.RESULTS As compared with the model control group,the activity of ALT in serum was significantly increased(P0.01),and the content of MDA in liver were significantly decreased(P0.01) in large,middle and small dosages of the Gankang paste groups,and the activities of SOD and GSH-Px in liver were significantly increased(P0.01,P0.05).CONCLUSION The Gankang paste has protective effects for acute liver injury induced by CCl4 in mice.

Key concepts: Carbon tetrachloride, CCL4, Dose, Subcutaneous injection, Liver injury, Chemistry, Glutathione, Pharmacology

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