2006•Zhongguo shiyan fangjixue zazhiRequires access

Protective Effects of Gankang on Chemical Liver Injury Induced by D-galactosamine in Mice

Wang Di-sheng

Abstract

Objective:To investigate the protective effects of Gankang on D-galactosamine-induced liver injury and study its possible mechanism.Methods:The model of chemical injury in liver of mouse was prepared.The level of alanine aminotransferase(ALT),aspartate aminotransferase(AST) in serum,malondiadehyde(MDA)content,nitric oxide(NO)in liver homogenate were assayed by spectrophotometer.Results:Gankang(200,400,800mg·kg~(-1))significantly decreased the levels of serum transaminase(ALT,AST),liver index and spleen index.Furthermore,Gankang also decreased MDA and NO level in liver homogenate.Conclusion:Gankang possesses protective action on chemical injury in liver of mice,which is related to its mechanism of ressistance to the liver cell oxidation.

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Key concepts: Liver injury, Nitric oxide, Galactosamine, Alanine transaminase, Chemistry, Aspartate transaminase, Alanine aminotransferase, Pharmacology