Distribution and drug resistance of pathogens causing lower respiratory tract infections in ICU patients

OBJECTIVE To investigate the distribution and drug resistance of pathogens causing lower respiratory tract infections in the ICU patients so as to provide evidence for the clinical reasonable use of antibiotics.METHODS The pathogenic bacteria were identified by VITEK32 system and the antibiotics susceptibility testing was performed by disc diffusion method,the statistical analysis was performed by WHONET 5.4.RESULTS Of the isolated pathogens causing lower respiratory tract infections in the ICU patients,there were 364(74.9%) strains of gram-negative bacteria and 84(17.3%) strains of gram-positive bacteria;126(25.9%)strains of Pseudomonas aeruginosa,101(20.8%)strains of Klebsiella pneumoniae,and 52 strains(10.7%)of Acinetobacter baumannii were the top 3 gram-negative bacteria;30(6.2%) strains of Staphylococcus aureus,21(4.3%) strains of Enterococcus,and 14(2.9%) strains of S.haemolyticus were the top 3 gram-positive bacteria;the gram-negative bacilli were most susceptible to imipenem and cefoperazone/sulbactam,and the gram-positive bacteria were highly susceptible to teicoplanin and vancomycin.CONCLUSION The gram-negative bacilli are the major pathogens causing lower respiratory tract infections in the ICU patients,thus it is necessary for the hospital to use antibiotics reasonably so as to reduce the drug resistance rate.