Distribution and drug susceptibility of pathogenic bacteria causing lower respiratory tract infections in children

OBJECTIVE To investigate the main pathogens causing lower respiratory tract infections in children and their drug resistance so as to provide basis for clinical rational use of antibiotics.METHODS A clinical retrospective analysis of the clinical data from Jan 2009 to Dec 2010 was performed for the children with lower respiratory tract infections.VITEK-32 System was used to identify the pathogesn and K-B method was used for the antibiotics susceptibility testing,the data of drug resistance was analyzed by using WHONET software.RESULTS A total of 63 strains of pathogenic bacteria were isolated,gram-negative bacteria were the dominant pathogens,accounting for 74.9%,the top 3 pathogens were in order as follows: Klebsiella pneumoniae(30.0%),Escherichia coli(22.9%),and Pseudomonas aeruginosa(9.9%);gram-positive bacteria were the next,accounting for 16.0%,the top three were Staphylococcus aureus(5.0%),Streptococcus pneumoniae(4.2%),and Staphylococcus hemolyticus(2.4%);the fungi were the third,accounting for 9.11%.The antibiotics susceptibility testing showed that gram-negative bacteria were susceptible to piperacillin/tazobactam,cefoperazone/sulbactam,and imipenem,and gram-positive cocci were susceptible to teicoplanin and vancomycin,as well as levofloxacin.CONCLUSION Gram-negative bacteria are the major pathogens causing lower respiratory tract infections in children,so the clinical monitoring should be strengthened and the antibiotics should be used reasonably.