Distribution of pathogens causing lower respiratory tract infections and drug resistance

OBJECTIVE To explore the species of pathogens causing lower respiratory tract infections and the their resistance to commonly used antibiotics,so as to guide the clinical use of antibiotics.METHODS A total of 120 patients with respiratory tract infections were selected,the bacterial cultures for the sputum and tracheal lavage specimens of all the patients were performed,the drug susceptibility testing was carried out.RESULTS Totally 132 strains of pathogens were cultured from 120 patients,there were 36(27.3%) strains of gram-positive bacteria,among which Staphylococcus aureus and S.epidermidis were dominant;there were 82(62.1%) strains of gram-negative bacteria,among which Pseudomonas aeruginosa,Escherichia coli,and Acinetobacter were dominant;there were 14(10.6%) strains of fungi,among which Candida albicans was the main species;the drug susceptibility testing showed that the drug resistance of gram-positive bacteria was the highest to the first generation of cephalosporins and the lowest to vancomycin,and the drug resistance of gram-negative bacteria was the lowest to imipenem.CONCLUSION The main pathogens causing lower respiratory tract infections are gram-negative bacteria,common infections can be treated with the quinolones or aminoglycoside antibiotics,severe infections can be treated with imipenem.