Protective Effects of Ligustrazine on Rat Kidney after Cardiopulmonary Resuscitation

Objective To investigate the protective effects and its mechanism of ligustrazine on rat kidney after cardiopulmonary resuscitation.Methods Thirty-six SD rats were randomly divided into sham group,model group and ligustrazine group.Cardiac arrest was induced with asphyxiation combined ice-cold potassium chloride.Twenty-four hours after resuscitation,the serum levels of urea and creatinine,renal SOD activities and MDA contents were detected,the apoptosis of renal tubular cells was assessed.Results Compared with sham group,the serum levels of urea and creatinine,renal MDA contents and the number of apoptotic cells were significantly increased(P0.01,respectively),the activity of renal SOD was significantly decreased in model group(P0.01).In ligustrazine group,the serum levels of urea and creatinine,renal MDA contents and the number of apoptotic cells were lower than that in model group(P0.01,respectively),renal SOD activity was higher than that in model group(P0.01).Conclusion Ligustrazine could protect renal function in rats after cardiopulmonary resuscitation,the mechanism is probably through alleviation of oxyradical injury and inhibition of tubular cell apoptosis.