Protective effects of ligustrazine on renal damage of acute ischemia-r eperfusion in mice

AIM: To investigate the effects of ligustrazine (LT) on rena l damage of acute ischemia-reperfusion in mice. METHODS: The mode l of renal ischemia-reperfusion in mice was established by clamping the right r enal pedicel in situ for 30 min before reperfusion of blood 15 min, 60 min, and 24 h. Treated the mice with LT100 mg·kg -1 ip (ligustrazine group) and saline ip (control group) 30 min before operation. The levels of serum creatini ne (Scr), blood urea nitrogen (Bun), content of malondialdehyde (MDA) and the ac tivity of superoxide dismutase (SOD) in serum and renal tissue, numbers of WBC a dhesion in renal tissue and scores of tubules were detected. RESULTS: LT lowered significantly MDA content and scores of tubules, the number of WBC adhesion, the levels of Scr, BUN, and increased the activity of SOD in renal tissues and serum. CONCLUSION: Ligustrazine may protect the ren al damage of acute ischemia-reperfusion, and the mechanism is to antagonize the free radical injury and to inhibit WBC adhesion.