Effects of Ligustrazine on Renal Damage of Acute Ischemia-Reperfusion in Mice

Objective:To investigate the effecte of ligustrazine on renal damage of acute ischemia-reperfusion in mice.Methods:The model of renal ischemia-reperfusion in mice was established by clamping the right renal pedicel in situ for 30 min before reperfusion of blood 15 min, 60 min,24 h. The levels of serum creatinine, blood urea nitrogen, malonyldehyde and the renal contents of water were detected.Results:The levels of serum creatinine, blood urea nitrogen and malonyldehyde was reduced significantly( P 0.01)in renal ischemia-reperfusion 24 h ligustrazine group and control group, increased the level of No( P 0.05)reperfusion 15 min, but the renal contents of water was no difference( P 0.05).Conclusion:Ligustrazine may protect the renal damage of acute ischemia-reperfusion in mice.