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2008•Zhongliu fangzhi yanjiuOpen access

Short-term Effects of Nedaplatin Plus Futraful Chemotherapy in Treatment of Advanced Esophageal Carcinoma

Ping Lü

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Abstract

Objective To observe the efficacy and the side effects of nedaplatin with futraful in the treatment of advanced esophageal carcinoma.Methods Observing group NDP/FT-207 regiment:given nedaplatin 80~100mg/m2 on day 1and futraful 500～600mg/m2 on day 1 to 5;control group:DDP/5-Fu regiment received cisplatin 80~100mg/m2 on day 1and 5-Fluorouracil 500~750mg/m2 on day 1 to 5.In both groups per 28 days was a cycle,2~3 cycles were one course.Results Response and toxicity could be assessed in all the 78 patients,42 patients were in observing group,the other 36 patiests were in control group.The response rate of patients treated by NDP/FT-207 and DDP/5-Fu were 57.1%(24/42)and 50%(18/36)respectively.The two groups have no significant difference.Conclusion The side effects as gastrointestinal reactions and myelosuppression etal in observing group is lighter than that in control group.

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Objective To observe the efficacy and the side effects of nedaplatin with futraful in the treatment of advanced esophageal carcinoma.Methods Observing group NDP/FT-207 regiment:given nedaplatin 80~100mg/m2 on day 1and futraful 500～600mg/m2 on day 1 to 5;control group:DDP/5-Fu regiment received cisplatin 80~100mg/m2 on day 1and 5-Fluorouracil 500~750mg/m2 on day 1 to 5.In both groups per 28 days was a cycle,2~3 cycles were one course.Results Response and toxicity could be assessed in all the 78 patients,42 patients were in observing group,the other 36 patiests were in control group.The response rate of patients treated by NDP/FT-207 and DDP/5-Fu were 57.1%(24/42)and 50%(18/36)respectively.The two groups have no significant difference.Conclusion The side effects as gastrointestinal reactions and myelosuppression etal in observing group is lighter than that in control group.

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Available abstract

Objective To observe the efficacy and the side effects of nedaplatin with futraful in the treatment of advanced esophageal carcinoma.Methods Observing group NDP/FT-207 regiment:given nedaplatin 80~100mg/m2 on day 1and futraful 500～600mg/m2 on day 1 to 5;control group:DDP/5-Fu regiment received cisplatin 80~100mg/m2 on day 1and 5-Fluorouracil 500~750mg/m2 on day 1 to 5.In both groups per 28 days was a cycle,2~3 cycles were one course.Results Response and toxicity could be assessed in all the 78 patients,42 patients were in observing group,the other 36 patiests were in control group.The response rate of patients treated by NDP/FT-207 and DDP/5-Fu were 57.1%(24/42)and 50%(18/36)respectively.The two groups have no significant difference.Conclusion The side effects as gastrointestinal reactions and myelosuppression etal in observing group is lighter than that in control group.

Key concepts: Nedaplatin, Medicine, Cisplatin, Fluorouracil, Chemotherapy, Internal medicine, Gastroenterology, Toxicity

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