Observation on the efficacy of nedaplatin combined with 5-fluorouracil in treatment of advanced esophageal cancer

Objective To compare the efficacy of nedaplatin(NDP) and cisplatin( DDP) combined with 5-fluorouracil(S-Fu) in treatment of advanced esophageal cancer.Methods 61 patients with advanced esophageal cancer were divided into two groups randomly,the observation group(NDP group) were 30 cases and the control group (DDP group) were 31 cases.NDP group were given NDP(80 ～ 100mg/m2, intravenous drip, 1 day) and 5-Fu (0.5g/m2,intravenous drip,l～5 day) ,DDP group were given DDP(80 ～100mg/m2 ,devided into 3 days) and5-Fu ( 0.5 g/m2 , intravenous drip ,1～5 day).The cycles were repeated every 4 weeks, and the effects were assessed after 2 cycles.Results The remisson rate of the observation group was 56.1% ,significantly higher than that of the control group (29.0% ) ( P <0.05).The toxicity of the observation group was milder for gastrointestinal tract but more serious for bone marrow than that of the control group (all P < 0.05).Conclusion NDP was an effective platinum drug for esophageal carcinoma.The efficacy of nedaplatin combined with 5-Fu regimen was better than that of DDP combined with 5-Fu regimen,and it had a good clinical tolerance and could be recommended as the first-line drugs. Key words: Esophageal neoplasm;  Nedaplatin;  Cisplatin