Expression of Twist in Ovarian Serous Cystadenocarcinoma and Its Significance

[Purpose] To analyze the relationship between Twist protein and ovarian serous cystadenocarcinoma.[Methods] The expressions of Twist protein in ovarian serous cystadenocarcinoma tissue,ovarian borderline serous cystadenoma tissue and serous cystadenoma tissue were detected immunohistochemically.[Results] The positive rates of Twist in ovarian serous cystadenocarcinoma,ovarian borderline serous cystadenoma and serous cystadenoma were 78.33%(94/120),37.50%(3/8) and 25.00%(2/8) respectively,with significant difference(χ2=16.119,P0.01).However,the difference between borderline serous cystadenoma and serous cystadenoma was not significant(χ2=0.291,P=0.590).There was no positive Twist expression case in 8 normal ovarian tissues.Twist expression associated with lymph node metastasis(P0.05),and did not associate with menopause,stage and histological grade(P0.05).[Conclusion] Twist is correlated to cacinogenesis of ovarian serous cystadenocarcinoma,and may be considered as one of indexes for predicting lymph node metastasis.