Expression of MUC1 in ovarian serous tumor and its clinical significance

Objective:To investigate the expression of MUC1 and its clinical significance in ovarian serous tumor.Methods: Using immunohistochemical technique(SP),we examined the expression of MUC1 in 53 ovarian serous cystadenocarcinoma tissues,20 borderline serous cystadenoma tissues and 20 benign serous cystadenoma tissues and 20 normal ovarian tissue.Results:The positive expression rate of MUC1 in ovarian serous cystadenocarcinoma was 88.7%,slightly higher than ovarian borderline serous cystadenoma(70%)(P=0.1172),obviously higher than benign serous cystadenoma(35%) and normal ovarian tissue(30%)(P0.05).The positive expression of MUC1 was correlated with clinical stage(P0.05),but not with age,histology grade and lymph node metastasis(P0.05).Conclusion:The expression of MUC1 significantly contributed to the carcinogenesis and subsequent progression in ovarian serous cystadenocarcinoma and might be used as a reference index of judging biological behavior and malignant potency in ovarian serous cystadenocarcinoma.