Expression of B7-H1 in Ovarian Serous Cystadenocarcinoma and Its Clinical Significance

Objective To investigate the relationship of B7-H1 protein expression in human ovarian serous cystadenocarcinoma to the clinicopathological characteristics and prognosis,and to provide an application in ovarian serous tumor diagnosis and target therapy.Methods The expression of B7-H1 protein was measured by immunohistochemistry PV-9000 two-step method in 40 serous cystadenocarcinoma specimens,20 serous borderline cystadenoma specimens and 20 serous cystadenoma specimens.Results The positive rate of B7-H1 protein expression was 15.0%,30.0% and 77.5% in serous cystadenoma,serous borderline cystadenoma and serous cystadenocarcinoma,respectively.The differences were statistically significant among the three groups(χ2=25.10,P=0.000).The expression of B7-H1 protein in serous cystadenocarcinoma was correlated with clinical stage(P0.05),but not correlated with patient age,pathological grade,tumor size,ascites cytology and lymph node metastasis(P0.05).Kaplan-Meier univariate survival analysis indicated that clinical stage and B7-H1 protein were the influencing factors of the prognosis in human ovarian serous cystadenocarcinoma(P=0.021 and P=0.000,respectively).Conclusion The expression of B7-H1 is correlated with the occurrence and development of ovarian serous cystadenocarcinoma and can be used as a useful marker for early diagnosis and prognosis evaluation in patients with ovarian serous cystadenocarcinoma.