Relationship of AKT1 with Occurrence and Chemo-resistance in Ovarian Serous Neoplasms

[Purpose]To investigate the relationship of AKT1 with occurrence and chemoresistance in ovarian serous neoplasms.[Methods]AKT1 expression in 67 cases with ovarian serous cystadenocarcinoma (30 cases,chemotherapy resistance;37 cases,chemotherapy sensitivity),10 cases with ovarian borderline serous cystadenoma,10 cases with ovarian serous cystadenoma and 10 cases normal ovarian tissues were detected immonohistochemically. [Results]The positive rates of AKT1 in ovarian serous cystadenocarcinoma,ovarian borderline serous cystadenoma,ovarian serous cystadenoma and normal ovarian tissues were 62.69%,70.00%,40.00% and 0 respectively,with significant difference(P=0.001). The positive rate of AKT1 in chemotherapy resistance ovarian serous cystadenocarcinoma was significantly higher than that in chemotherapy sensitive ovarian serous cystadenocarcinoma(P=0.033). The positive rates of AKT1 in ovarian serous cystadenocarcinoma stage Ⅰ～Ⅱ and Ⅲ～Ⅳ were 31.58% and 75.00%,respectively,with significant difference(P=0.001). The positive rate of AKT1 did not correlate with menopausal status,histological grade and lymph node metastasis(P0.05).[Conclusion]AKT1 correlates with occurrence and chemoresistance in ovarian serous cancer. It may be considered as a marker for predicting prognosis and chemoresistance.