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2010•Chinese Journal of PharmaceuticalsRequires access

Determination of Residual Organic Solvents in Bisphosphonates by Headspace Capillary Gas Chromatography

Ye Jiang

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Abstract

An headspace capillary gas chromatography method was established for the determination of methanol,ethanol,acetone and chlorobenzene in bisphosphonates with ionic liquid as matrix medium.A DB-624 capillary column was used with temperature program and FID detector,at injection temperature 120 ℃ and equilibrium time 20 min.The recoveries were 97.1%-100.3%,with the RSDs less than 3.0%.Their detection limits were 0.15,0.06,0.06 and 0.007 μg/ml,respectively.

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An headspace capillary gas chromatography method was established for the determination of methanol,ethanol,acetone and chlorobenzene in bisphosphonates with ionic liquid as matrix medium.A DB-624 capillary column was used with temperature program and FID detector,at injection temperature 120 ℃ and equilibrium time 20 min.The recoveries were 97.1%-100.3%,with the RSDs less than 3.0%.Their detection limits were 0.15,0.06,0.06 and 0.007 μg/ml,respectively.

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Available abstract

An headspace capillary gas chromatography method was established for the determination of methanol,ethanol,acetone and chlorobenzene in bisphosphonates with ionic liquid as matrix medium.A DB-624 capillary column was used with temperature program and FID detector,at injection temperature 120 ℃ and equilibrium time 20 min.The recoveries were 97.1%-100.3%,with the RSDs less than 3.0%.Their detection limits were 0.15,0.06,0.06 and 0.007 μg/ml,respectively.

Key concepts: Chemistry, Chlorobenzene, Chromatography, Gas chromatography, Capillary action, Acetone, Methanol, Detection limit

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