Determination of Residual Organic Solvents in Risperidone by Headspace Capillary GC

A headspace capillary gas chromatography method was established for the determination of methanol,acetone,isopropanol,acetonitrile,dichlormethane,hexane,ethyl acetate and toluene in risperidone.A DB-624 capillary column was used with temperature program and FID detector,at injection temperature of 85 ℃ and equilibrium time of 20 min.The calibration curves of these solvents were linear in the concentration ranges of 9-900,15-1 500,15-1 500,1.2-120,1.8-180,0.9-90,15-1 500 and 2.7-270 μg/ml,respectively.The recoveries were 99.4%,96.4%,104.4%,99.7%,96.3%,96.3%,97.1% and 96.8%,with RSDs less than 2.5%.