Determination of Residual Organic Solvents in Clopidogrel Hydrogen Sulfate by Headspace Capillary Gas Chromatography

A headspace capillary gas chromatography method was established for the determination of methanol,acetone,isopropanol,dichlormethane,isopropyl ether and ethyl acetate in clopidogrel hydrogen sulfate.The samples were pre-treated with magnesium oxide.A DB-624 capillary column was used with temperature program and FID detector,at injection temperature of 70 ℃ and equilibrium time of 30 min.The calibration curves of these solvents were linear in the concentration ranges of 7.5-750,5-500,12.5-1 250,1.5-150,12.5-1 250 and 12.5-1 250 μg/ml,respectively.The recoveries were 100.4%,101.2%,100.5%,98.2%,99.2% and 99.6%,with RSDs less than 2.0%.