Relationships of serum total bile acids,cholesterol and AST/ALT ratio with the Child-Pugh classification in cirrhosis

Objective:To study the possible relationships of serum total bile acids (TBA),cholesterol (CHO) and AST/ALT ratio to different Child-Pugh classifications in patients with HBV-related cirrhosis. Methods:Selected clinically diagnosed 76 cases of patients with liver cirrhosis according to Child-Pugh score for classification (grade A,B and C) as the cirrhosis group,48 cases of healthy persons were served as the control group,the serum TBA,CHO and AST/ALT ratio of the two groups were detected. Results:Compared with the control group,the serum TBA of cirrhosis group increased,serum CHO reduced,AST/ALT ratio increased,they showed significant difference (P0.01). Patients with liver cirrhosis according to Child-Pugh classification had significant difference among grade A,B and C (P0.01). Conclusion:Patients with liver cirrhosis with serum TBA,CHO and AST/ALT ratio of the joint detection helps classification of liver function in patients with liver cirrhosis,and helps to assess the degree of liver dysfunction.