Analysis of serum total bile acid in patients with liver cirrhosis

Objective:To study the changes of serum bile acid in patients with liver cirrhosis,and to explore the role of serum bile acid in evaluation of liver cirrhosis severity.Methods:A total of 59healthy volunteers served as control group,89patients with cirrhosis at different Child-pugh classification were selected as cirrhosis group.Correlation between indexes of liver function and Child-pugh score was analyzed.Results:There were significant differences in TBA,TBIL,ALT and AST between two groups(P0.05),and all indexes in cirrhosis group were increased at different degree;The differences in TBA,TBIL were significant among groups at different Child-pugh classification(P0.05).The difference in ALT was not significant between B and C grade level group(P0.05),and the difference in AST was not significant between group A and B grade level group(P0.05);TBA(r=0.692,P0.05),TBIL(r=0.529,P0.05)and Child-pugh score was positively correlated.Conclusion:Serum TBA has correlation with Child-pugh score.It can reflect the severity of cirrhosis,and is valuable in early diagnosis of liver cirrhosis and condition assessment.