Analysis of Curative Effect of Combined Chinese and Western Medicine on 48 Patients Suffered from Severe Acute Pancreatitis with Secondary Infection

Objective To observe the clinical curative effect of integrative Chinese and western medicine on severe acute pancreatitis(SAP) with secondary infection.Methods 96 caese with SAP were divided randomly into approach group(n=48)and control group(n=48).Both group were given routine western medicine,but in approach group the patients were additionally administered with Rhubarb and Mangxiao.Their main clinical signs were observed.The plasma levels of TNF-a,IL-6 and LPS were examined.The incidence of gastrointestinal failure,secondary infection and mortality were also investigated.Results The incidence and duration of main clinical signs,gastrointestinal failure and secondary infection in approach group were significantly lower than those in control group.The plasma levels of TNF-a,IL-6 and LPS in treatment group decreased sharply.Although the overall mortality in approach group was also lower than that in control group,there was not statistical difference between two group(P0.05).Conclusion Rhubarb and Mangxiao could promote the early recovery of gastrointestinal function and protect the but barrier,which may decrease intestinal endotoxin translocation,relieve systemic inflammatory reation and reduce the incidence of secondary infection.