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2005•Unpublished venueRequires access

Determination of Concentration of Carbamazepine in Human Plasma by HPLC

Gao Yong

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Abstract

Objective To establish a rapid, convenient and accurate method to determine the concentration of car-bamazepine in human plasma. Methods The concentration of carbamazepine was determined by RP-HPLC. Results The linearity range was 0.4-25μg/ml with a regressive equation of Y= 12.5X + 0.142 5, r = 0.996 0. The recovery rate was 97.5 % . RSD was 1.5% (intra-day) and 2.3% (inter-day) . Conclusion The method is accurate and rapid and suitable for determination of carbamazepine in human plasma.

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What this paper is about

Objective To establish a rapid, convenient and accurate method to determine the concentration of car-bamazepine in human plasma. Methods The concentration of carbamazepine was determined by RP-HPLC. Results The linearity range was 0.4-25μg/ml with a regressive equation of Y= 12.5X + 0.142 5, r = 0.996 0. The recovery rate was 97.5 % . RSD was 1.5% (intra-day) and 2.3% (inter-day) . Conclusion The method is accurate and rapid and suitable for determination of carbamazepine in human plasma.

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Available abstract

Objective To establish a rapid, convenient and accurate method to determine the concentration of car-bamazepine in human plasma. Methods The concentration of carbamazepine was determined by RP-HPLC. Results The linearity range was 0.4-25μg/ml with a regressive equation of Y= 12.5X + 0.142 5, r = 0.996 0. The recovery rate was 97.5 % . RSD was 1.5% (intra-day) and 2.3% (inter-day) . Conclusion The method is accurate and rapid and suitable for determination of carbamazepine in human plasma.

Key concepts: Carbamazepine, Human plasma, Chromatography, High-performance liquid chromatography, Chemistry, Plasma concentration, Plasma, Pharmacology

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