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2008•Journal of Hunan Normal UniversityRequires access

Determination of Concentration of Carbamazepine in Human Plasma by RP-HPLC

Hui Li

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Abstract

Objective To establish a rapid,convenient and accurate method to determine the concentration of carbamazepine in human plasma.Methods The concentration of carbamazepine was determined by RP—HPLC.Results The linearity range was 1.0—20μg/mL with a regressive equation of C=0.0422R─0.2565,r=0.9998.respectively.The intra—day RSD of and the inter—day RSD were 3.5%—4.2% and 4.2%—5.0% respectively.The relative recoveries carbamazepine were 101.6%.Conclusion The method is accurate and rapid and suitable for determination of carbamazepine in human plasma.

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What this paper is about

Objective To establish a rapid,convenient and accurate method to determine the concentration of carbamazepine in human plasma.Methods The concentration of carbamazepine was determined by RP—HPLC.Results The linearity range was 1.0—20μg/mL with a regressive equation of C=0.0422R─0.2565,r=0.9998.respectively.The intra—day RSD of and the inter—day RSD were 3.5%—4.2% and 4.2%—5.0% respectively.The relative recoveries carbamazepine were 101.6%.Conclusion The method is accurate and rapid and suitable for determination of carbamazepine in human plasma.

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Available abstract

Objective To establish a rapid,convenient and accurate method to determine the concentration of carbamazepine in human plasma.Methods The concentration of carbamazepine was determined by RP—HPLC.Results The linearity range was 1.0—20μg/mL with a regressive equation of C=0.0422R─0.2565,r=0.9998.respectively.The intra—day RSD of and the inter—day RSD were 3.5%—4.2% and 4.2%—5.0% respectively.The relative recoveries carbamazepine were 101.6%.Conclusion The method is accurate and rapid and suitable for determination of carbamazepine in human plasma.

Key concepts: Carbamazepine, Chromatography, Human plasma, Chemistry, Plasma concentration, High-performance liquid chromatography, Plasma, Pharmacology

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