Significance of determination of sOX40L and matrix metalloproteinases-9 in patients with coronary artery disease

Objective To explore the relationship between sOX40L, MMP-9 and stability of coronary atherosclerotic plaque in patients with coronary heart disease (CHD). Methods The morphology of plasma sOX40L and MMP-9 were determined with ELISA.. All patients were identified with coronary angiography (CAG) . All coronary stenoses with ≥ 50% diameter reduction were assessed by angiographic coronary stenosis morphology. Results (1) the level of serum sOX40L and MMP-9 in ACS group were significantly higher than SA and control groups ( P 0.05) . But there was no significant difference between SA group and control group ( P0.05) ;(2) the score of angiography morphology of coronary lesions in ACS group was significantly higher than that of SA and control groups ( P 0.05). But there were no significant difference between SAP group and control group ( P 0.05);(3) the levels of sOX40L and MMP-9 were correlated with the coronary severity scores (r1 =0.52 p0.05, r2 =0.41 p0.05).(4) Correlation analysis suggested the levels of sOX40L were positively correlated with MMP-9 (p0.05). Conclusion The elevated levels of serum sOX40L, MMP-9 in ACS suggested that they may enhance the inflammation , aggravate the development of atherosclerosis and mediate the plaque destabilization . They can be served as a valuable marker for evaluating the degree of coronary artery pathology and forecasting clinical risk in ACS.