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2009•Unpublished venueRequires access

Clinical study of oxaliplatin plus 5-FU/CF in treatment of advanced gastric cancer

Zhang Peng-tian

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Abstract

Objective:To evaluate the therapeutic effect and toxicity of oxaliplatin (L-OHP) plus 5-FU+CF in advanced gastric cancer.Methodas:Thirty-one patients with advanced gastric cancer received L-OHP plus 5-FU/CF.L-OHP 130mg/m2 was administered,iv infusion four hour d1,leucovorin (CF) 150mg/m2,iv infusion for two hour d1-d5,followed by 5-FU 500mg/m2 iv infusion over a period of four hours d1-d5.This regimen was repeated every 3 weeks.Results:Among 31 patients,there were CR 1,PR 14,the overall response rate (CR+PR) was 48.39%.The major toxicities were nausea and vomiting,neurosensory toxicity,neutropenia,but they were tolerable.Conclusion:The combination of oxaliplatin and 5-FU/CF is an effective and tolerable regimen for treatment of advanced gastric cancer.

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What this paper is about

Objective:To evaluate the therapeutic effect and toxicity of oxaliplatin (L-OHP) plus 5-FU+CF in advanced gastric cancer.Methodas:Thirty-one patients with advanced gastric cancer received L-OHP plus 5-FU/CF.L-OHP 130mg/m2 was administered,iv infusion four hour d1,leucovorin (CF) 150mg/m2,iv infusion for two hour d1-d5,followed by 5-FU 500mg/m2 iv infusion over a period of four hours d1-d5.This regimen was repeated every 3 weeks.Results:Among 31 patients,there were CR 1,PR 14,the overall response rate (CR+PR) was 48.39%.The major toxicities were nausea and vomiting,neurosensory toxicity,neutropenia,but they were tolerable.Conclusion:The combination of oxaliplatin and 5-FU/CF is an effective and tolerable regimen for treatment of advanced gastric cancer.

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Available abstract

Objective:To evaluate the therapeutic effect and toxicity of oxaliplatin (L-OHP) plus 5-FU+CF in advanced gastric cancer.Methodas:Thirty-one patients with advanced gastric cancer received L-OHP plus 5-FU/CF.L-OHP 130mg/m2 was administered,iv infusion four hour d1,leucovorin (CF) 150mg/m2,iv infusion for two hour d1-d5,followed by 5-FU 500mg/m2 iv infusion over a period of four hours d1-d5.This regimen was repeated every 3 weeks.Results:Among 31 patients,there were CR 1,PR 14,the overall response rate (CR+PR) was 48.39%.The major toxicities were nausea and vomiting,neurosensory toxicity,neutropenia,but they were tolerable.Conclusion:The combination of oxaliplatin and 5-FU/CF is an effective and tolerable regimen for treatment of advanced gastric cancer.

Key concepts: Oxaliplatin, Medicine, Nausea, Vomiting, Regimen, Neutropenia, Toxicity, Gastroenterology

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