The Effect of Ligustrazine and Alprostadil on the Early Diabetic Nephropathy

Objective: Ligustrazine and Alprostadil treatment of the early diabetic nephropathy.Methods: 120 patients with early type 2 diabetes of hospitalization were collected and randomly divided into 3 groups: Ligustrazine group(40 cases),Alprostadil group(40 cases),combined therapeutic group(40 cases).All cases were observed for 2 weeks.The changes of serum creatinine(Cr),blood urea nitrogen(BUN),24 hour urinary albumin before and after the treatment were compared.Results: After treatment for 2 weeks,the treatment of combined therapeutic group in decreasing 24 h urinary albumin was better than Ligustrazine group and Alprostadil group,the differences were significant(P0.05).The differences between Ligustrazine group and Alprostadil group were significant(P0.05).Conclusion: The treatment of Alprostadil combined with Irbesartan in early diabetic nephropathy is an effective way.Intravenous ligustrazine and alprostadil can delay the progression of diabetic nephropathy.It would be valuable to widespread popularization.