Effects of Alprostadil Injection Combined with Danshen Injection on Early Diabetic Nephropathy

Objective To observe the effect of Alprostadil injection combined with Danshen injection in the treatment of early diabetic nephropathy.Methods 120 patients with early diabetic nephropathy were randomly divided into Alprostadil group(60 cases) and combined treatment group(60 cases).All the patients were given diabetes diet,blood sugar control and blood pressure control as well as blood fat adjustment.The Alprostadil group was given Alprostadil injection(20 μg,once/day).The combined treatment group was given Alprostadil injection(20 μg,once/day) and Danshen injection(20 ml,once/day).The course of treatment was four weeks.The changes of total cholesterol(TC),triglyeride(TG),high density lipoprotein(HDL-C),low density lipoprotein(LDL-C),blood urea nitrogen(BUN),serum creatinine(Cr),urinary albumin excretion rate(UAER) and β2-MG in the two groups were observed before the treatment and after the four weeks treatment.Results The levels of TC,TG,LDL-C,Cr,BUN,UAER and β2-MG in the two groups were all significantly decreased after treatment(P0.05),while the level of HDL-C was significantly increased after treatment(P0.05).The improvement level of the above mentioned parameters was significantly better in the combined treatment group than in the Alprostadil group(P0.05).Conclusion Combined treatment of Alprostadil injection and Danshen injection is effective in the treatment of early diabetic nephropathy.