Expression of HSP70 and p53 and Their Relationship with Pathological Characteristics in Papillary Thyroid Carcinoma

Objective: To investigate the relationship of the expression of HSP70 and p53 with the pathological characteristic in papillary thyroid carcinoma.Methods: The expression of HSP70 and p53 protein were detected with immunohistochemical EnVision plus non-hiotin technique in 35 cases of papillary thyroid carcinoma,15 cases of benign thyroid diseases and 15 cases of normal tissues of thyroid.Results: The positive expression rates of HSP70 and p53 protein in papillary thyroid carcinoma were significantly higher than that in benign thyroid diseases and normal tissues of thyroid(P0.01).The expression of HSP70 was positively related to lymph node metascasis,AJCC clinical stage and the degree of infiltration(P0.01).The expression of p53 was positively related to AJCC clinica1 stage,differentiation degree,lymph node metascasis and the degree of infiltration(P0.01).The expression of HSP70 was positiye1y correlated with p53(r=0.679,P0.01).Conclusion: The expression of HSP70 and p53 protein in papillary thyroid carcinoma were high.There was the synergistic effect between HSP70 and p53.HSP70 and p53 protein may act as markers predicting biological behavior and prognosis of papillary thyroid carcinoma.