2011•Zhongguo linchuang baojian zazhiRequires access

Expression and significance of VEGF and ECM-1 in the tissue of human gastric cancer

Tao Yong

Abstract

Objective To investigate the changes VEGF,ECM-1 expression in gastric cancer tissues and its clinical and pathological features of gastric cancer and the relationship between the correlation between the availability.Methods Vascular endothelial growth factor(VEGF) and ECM-1 expression in gastric cancer and normal gastric tissues were detected by immunohistochemical method.Results(1) VEGF / ECM-1 protein in gastric cancer tissues and normal gastric tissue between the two groups was significant(P0.01).(2) There were significant difference in VEGF / ECM-1 expression among different histological grade,depth of tumor invasion,different TNM stage and whether there was lymph node metastasis(P0.05).(3) VEGF was positively correlated to ECM-1 protein expression.Conclusions VEGF,ECM-1 in gastric cancer tissues showed high expression of the state,and both the expression and clinicopathological features of gastric cancer are related.

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Key concepts: Medicine, Immunohistochemistry, Pathological, Cancer, Pathology, Vascular endothelial growth factor, VEGF receptors, Stage (stratigraphy)