2010•China Modern DoctorRequires access
Expression of P16 and VEGF Proteins in Gastric Cancer and Its Clinical Significance
Hong Yang
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Abstract
Objective To explore the expression of P16 and VEGF proteins in the gastric cancer tissue and the relationship between their expression and the occurrence and development of gastric cancer. Methods The P16 and VEGF expression in 60 cases of gastric cancer and its adjacent tissue was detected by MaxVisionTM immunohistochemical method. Results The positive rate of P16 protein was 68.33(41/60, P0.05),and the P16 protein expression was correlated with gastric cancer tissue differentiation,cancer infiltration,lymph node metastasis and nerve infiltration. The positive rate of VEGF was 61.67%(37/60,P0.05). The VEGF protein expression was not correlated with gastric cancer tissue differentiation and cancer infiltration,but was correlated with lymph node metastasis and nerve infiltration. Conclusion The expression of P16 and VEGF proteins is closely correlated with the occurrence,development and prognosis of gastric cancer,which can be used to evaluate the biological behavior and prognosis of gastric cancer.