Expression of Id-1 and VEGF in gastric cancer and its significance

Objective To investigate the expression of inhibitor of differentiation/DNA binding-1(Id-1) and vascular endothelial growth factor(VEGF) in gastric cancer,and their relationships with the clinicopathologic characteristics,and to investigate the correlations among them.Methods The expression of Id-1 and VEGF in 55 cases of gastric cancer and 15 cases of normal gastric tissue was detected by tissue microarray and SP immunohistochemical method.The correlations among the expressions of Id-1 and VEGF,and their relationships with the clinicopathologic features of gastric cancer were analyzed.Results The rates of positive expression of Id-1 and VEGF were 61.8% and 74.5% in gastric cancer and were significantly higher than those in normal gastric tissue(all P0.05).The expression level of Id-1 was positively correlated with the depth of tumor invasion,lymph node metastasis,TNM staging and differentiated degree of gastric cancer(all P0.05).The expression level of VEGF was positively correlated with the depth of tumor invasion,lymph node metastasis and TNM staging,while it had no significant relationship with differentiated degree of gastric cancer(P0.05).The expressions of Id-1 were positively correlated with the expressions of VEGF(rs=0.525,P0.01).Conclusions Overexpressions of Id-1 and VEGF might contribute to the tumorigenesis and malignant behaviors of gastric cancer.Detecting the expression leves of Id-1 and VEGF probably can predict the prognosis of gastric cancer.