Study on the Levels of Serum Interleukin-1β and Interleukin-6 in Patients with Progressive Cerebral Infarction

Objective To analyze the levels of serum interleukin-1β(IL-1β)and interleukin-6(IL-6)in patients with progressive cerebral infarction and explore its possible pathogenesis.Methods Sixty-six patients with cerebral infarction were divided into progressive group and non-progressive group according to pathological progression after admission into hospital,33cases in each group.They were divided into small,middle and large infarction groups,22cases in each group.Meanwhile,40healthy people were selected as control group.5mL of venous blood from each fasting patient was drawn in the morning.Enzyme-linked immunosorbent assay(ELISA)was used to detect the levels of IL-1βand IL-6.Results The levels of serum IL-1βand IL-6in progressive and nonprogressive groups were significantly higher than that in control group,and those in progressive group obviously higher than non-progressive group.The levels of serum IL-1βand IL-6in middle and large infarction groups were significantly higher than that in small infarction group,and those in large infarction group obviously higher than middle infarction group.The incidence of percutaneous coronary intervention(PCI)in large infarction group was notably higher than that in small infarction group.Conclusion The levels of serum IL-1βand IL-6in patients with cerebral infarction are associated with infarction volume,and have an early warning significance for the occurrence of progressive cerebral infarction.